Title: The pleiotropic vasoprotective functions of high density lipoproteins (HDL)


Authors: Guilaine Boyce, Emily Button, Sonja Soo, Cheryl Wellington


Institution: Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.


Abstract: The pleiotropic functions of circulating high density lipoprotein (HDL) on peripheral vascular health are well established. HDL plays a pivotal role in reverse cholesterol transport and is also known to suppress inflammation, endothelial activation and apoptosis in peripheral vessels. Although not expressed in the central nervous system, HDL has nevertheless emerged as a potential resilience factor for dementia in multiple epidemiological studies. Animal model data specifically support a role for HDL in attenuating the accumulation of β-amyloid within cerebral vessels concomitant with reduced neuroinflammation and improved cognitive performance. As the vascular contributions to dementia are increasingly appreciated, this review seeks to summarize recent literature focused on the vasoprotective properties of HDL that may extend to cerebral vessels, discuss potential roles of HDL in dementia relative to brain-derived lipoproteins, identify gaps in current knowledge, and highlight new opportunities for research and discovery.


Keywords: high density lipoprotein, vascular function, vascular disease, alzheimer disease, HDL-proteome, HDL-lipidome


Full Text:JBR-2016-0103.pdf


J Biomed Res published on January 15, 2017, doi: 10.7555/JBR.31.20160103